Tainted romaine lettuce is being blamed for four more deaths, bringing the total to five deaths related to a strain of E. coli, say federal health officials.
Numerous new cases were people who became ill two to three weeks ago, when contaminated lettuce was still being sold.
In the past two weeks an additional 25 people have also become ill from eating the contaminated lettuce, the CDC announced. The new CDC report announces four more deaths - one in Arkansas, two in Minnesota and one in NY. Deaths have been confirmed in Arkansas, California, Minnesota and NY with two of those deaths happening in Minnesota.
Romaine lettuce from the Yuma growing region in Arizona is thought to be the source of the latest E. coli outbreak. Since lettuce has a 21-day shelf life, it is unlikely that any romaine lettuce from the area remains in restaurants, stores or people's homes, the CDC said.
Officials said that first illness began sometime between March 13 and May 12.
Romaine lettuce grown in the Arizona region was last harvested in mid-April.
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Numerous new cases were people who became ill two to three weeks ago, when contaminated lettuce was still being sold. At least 89 were hospitalized.
"Any contaminated product from the Yuma growing region has already worked its way through the food supply and is no longer available for consumption", said FDA Commissioner Scott Gottlieb.
"Some people who became sick did not report eating romaine lettuce, but had close contact with someone else who got sick from eating romaine lettuce".
When eaten, E. coli can cause diarrhoea, vomiting and even kidney failure in severe cases.
The recent E. coli outbreak is the most severe to hit the USA since 2006, when three people died in an outbreak linked to uncooked spinach.