Police said a "small number of people" have been treated for injuries by medics at the scene.
Police said the "minor explosion", at about 19:00 BST, was thought to have been caused by a battery short circuit.
A large cordon is now in place and the station remains closed. "No serious injuries reported and enquiries continue", confirmed British Transport Police.
An earlier statement from the force said: "Met officers are dealing with a suspicious package at #Southgate tube station.
A small number of people have been treated at the scene", writes the Telegraph.
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London Mayor Sadiq Khan warned people to "avoid the area".
"I was at Southgate Station when this commotion started". Cordons are in place and the station is closed.
Some accounts indicate that there was a tipoff of a suspicious package which was being investigated by the police at the time of the explosion. British Transport Police said the incident was not thought to be terror-related.
At least five people have been injured after an explosion at an underground train station in north London.
"The scene has been examined by specialist officers". It appears at this stage that the cause of the explosion was a battery short circuit.