The Atlantic hurricane's maximum sustained winds have increased to almost 130 miles per hour (195 kilometers per hour), the National Hurricane Center (NHC) said in an advisory issued at noon Eastern Time (1600 GMT).
A Category 4 hurricane can cause catastrophic damage, the hurricane center warned: "Well-built framed homes can sustain severe damage with loss of most of the roof structure and/or some exterior walls", the hurricane center said. He described the storm as "extremely large and risky".
Hurricane Floyd came ashore in North Carolina as a Category 2 in 1999, bringing a 9 to 10-foot storm surge, according to the National Hurricane Center. This map shows the estimated arrival time of tropical storm force winds.
"Pretend, assume, presume that a major hurricane is going to hit right smack dab in the middle of SC and is going to go way inshore".
"Isaac is a small hurricane and uncertainty in the forecast is higher than normal, NHC Forecaster John Cangialosi said in Monday's forecast discussion".
The NHC said Florence is 1,170 miles east-southeast of Cape Fear in North Carolina, moving west-northwest at 13 mph. "However, there remains high confidence that Florence will be a large and extremely risky hurricane, regardless of its exact intensity", said the NHC in its discussion.
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SC has ordered the mandatory evacuation of its entire coast, and evacuations were also ordered for several North Carolina towns, as Category 4 Hurricane Florence continues her aggressive pursuit towards the states. "Flooding is the deadliest result of these storms".
The governors of North and SC and Virginia declared states of emergency far ahead of the approaching storm.
Mr Trump wished his best to the residents of the Carolinas.
Where the center of the storm is located, the intensity and size of the wind field are all factors in what impacts an area will see, but Eastern North Carolina residents should be prepared for a major storm event. Vessels that can't leave port will prepare by a variety of means, from adding mooring and storm lines to dropping anchor and disconnecting shore power cables.
The Center projects wind speed will continue to increase, potentially elevating Florence to a Category 5.
September 10 is the peak of the hurricane season in the Atlantic and the time when the strongest hurricane develop. Of the two other storms, which remain far from land, Isaac poses the most immediate risk.