Six-time US Open victor Williams, who remains one short of Margaret Court's record haul of 24 major singles titles, was initially disgusted after receiving a coaching violation from the umpire during the first set.
Later on, Williams received a point penalty for breaking her racket in frustration where she again went after Ramos.
Mouratoglou says that "in 99 percent of the cases, he would have told Serena, 'I've seen your coach do a movement and tell him to stop, otherwise you'll have a warning". You will never be on a court of mine as long as you live.
"She fought for her life, for our child, for recognition, for equal pay, for women's rights".
Osaka held serve to level the score at 3-3, and then broke Williams the following game, coolly slapping a forehand victor past Williams at 30-40 to clinch the break.
Williams called the tournament referee onto the court and began crying as she explained her version of events.
Williams was gracious as Osaka wrapped up her first Grad Slam title, as she urged the crowd at Arthur Ashe stadium to applaud the newly crowned champion. "This is her first Grand Slam".
"Then when I sat down, I said, 'Just to be clear, I can understand what you saw. You think, okay, she's going to let up eventually, but she didn't, so all credit to her". Let's not boo any more.
Williams was livid. "You owe me an apology", she shouted. "She deserved credit, she deserved to win".
"I know everyone was cheering for her and I'm sorry it had to end like this", a tearful Osaka said on the victory stand.
Serena Williams cited Tiger Woods as an inspiration after reaching the final of the US Open with a demolition of Anastasija Sevastova at Flushing Meadows. "I'd rather lose. I'm just letting you know".
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But her opponent, Serena Willams, and tennis fans alike were left wondering what was going on after a freaky circumstances cost Williams a game in the second set of Osaka's 6-2, 6-4 win.
A match with history at stake for both players got off to a tense start.
After a confident hold punctuated by a 106 miles per hour ace Osaka broke again to lead 4-1, silencing the Arthur Ashe Stadium crowd.
Serena, as usual, was a tremendous sport about it all with Osaka despite the umpire significantly shifting the second set. He punished her a game.
Down 3-4 in the set, Williams told Ramos, "You stole a point from me and you are a thief".
In an on-court interview with ESPN, Osaka was questioned on how she continued to deny her opponent a break and provoked laughter with her response.
She was then docked a point for a second violation when she smashed her racket. During the U.S. Open, a female player, Alize Cornet, was incorrectly admonished by a chair umpire for changing her shirt during a match, which is allowed - and which men do all the time.
"If I look at my box and they say, "C'mon" or "Good job", I don't know what else to do". That penalty put Osaka up 5-3, meaning she only needed one more game to win the match. For tonight, it is time to celebrate these two wonderful players, both of whom have great integrity.
Serena, instead, alleged the chair umpire for double standards and said that she was a victim of sexism.
Williams said she didn't know if she would have managed to turn things around if the dispute with Ramos had not occurred. I'm just a tennis player playing another tennis player.