Interpol said it used law-enforcement channels to submit its request for information about Meng's status.
Meng has been missing since he travelled to China at the end of September, his wife said.
On Friday, the French police started an investigation after the Meng's wife reported that he was missing, unidentified police officials told Reuters.
A source familiar with the investigation said the working assumption was that the 64-year-old had antagonised Chinese authorities and had been detained as a result.
A former vice minister of public security in China, he is the first Chinese national to hold the post.
There have been several cases in recent years of senior Chinese officials vanishing without explanation, only for the government to announce weeks or even months later that they have been put under investigation, often for suspected corruption.
Meng's appointment as president in 2016 - amid Chinese leader Xi Jinping's sweeping anti-corruption drive - alarmed some human rights organizations, fearful it would embolden China to strike out at dissidents and refugees overseas.
Interpol, which groups 192 countries and which is usually focused on finding people who are missing or wanted, said in a statement from its secretary general, Juergen Stock, that it had asked China for clarification.
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The newspaper said that upon landing last week Meng was "taken away" for questioning by what it said were "discipline authorities".
As of now, no official from either the public security nor the foreign ministry in China has commented on the issue.
The only clue has come from the Hong Kong-based South China Morning Post, which has strong sources... His wife has since reported him missing.
However, his appointment was an alarming sign of China's ability to shape worldwide organisations, including those in which its authoritarian influence was extremely unsafe, she said.
It does not have agents of its own with powers of arrest.
Meng rose up the ranks of the country's domestic security apparatus when it was under the leadership of Zhou Yongkang, a rival to Xi and the highest-ranking official to be brought down on corruption charges.
Meng was appointed head of Interpol in 2016, and was due to serve until 2020. According to Interpol's website, in May he delivered a speech in Ireland in which he discussed the changing face of global crime and the need for Interpol to remain above political considerations.