Almost 40 percent of voters cast their ballots to express opposition to the president, according to AP VoteCast, a national survey of the electorate, while one-in-four said they voted to express support for Trump.
Discussion about the possibility of impeaching the President is also likely to grow louder in a Democratic-controlled House, despite the fact that Democratic congressional leaders have tried to tamp down on speculation that the party might pursue impeachment - at least at this point.
From Florida to Texas to Illinois, Republican incumbents who survived reelection in 2016 even as Trump lost their districts fell decisively to Democratic challengers who linked them to the president and attacked their votes on health care and taxes previous year, delivering a check-and-balance message to the president.
Still, Trump brushed off criticism that he was alienating moderate voters as he continued his massive rallies and overheated rhetoric.
Democrats are poised to reclaim the U.S. House, fueled by voter anger and discontent with President Donald Trump to a victory that would dramatically alter his next two years in office and make a deeply divided nation even more hard to govern. Kamala Harris, former New York City Mayor Tom Steyer and former Vice-President Joe Biden.
With control of the lower chamber, Democrats will regain powerful oversight and subpoena powers they can use to investigate the Trump administration.
Still, a House controlled by the Democrats will hamper Trump's business-friendly agenda and could lead to uncertainty about his administration at a time when investors are already anxious that a decade-old bull market may be ending.
Casey won his third term against Republican challenger and Congressman Lou Barletta of Pennsylvania's current 11th District.
Democrats plan Russia-related investigations, such as a probe of possible business ties and conflicts of interest between Trump and Russian Federation.
Trump waited until late in the night to weigh in on the midterm vote, tweeting a succinct message that overlooked expected Democratic gains in the House, writing: "Tremendous success tonight". Voters will also elect 36 governors and hundreds of state and local government representatives.
Democratic senators went down in Indiana, Missouri and North Dakota, and others incumbents could yet suffer a similar fates in Florida and Montana. In suburban Chicago, Republican Representative Peter Roskam, a key architect of the 2017 tax overhaul, was defeated by Democrat Sean Casten.
Trump hopes that trade agreement with China will be finalized at G20
A key point of contention for the U.S. has been its allegations that China has engaged in widespread intellectual property theft. Neither leader specified any details of potential progress in their first known direct discussion in several months.
Turkey's Erdogan: Khashoggi killing ordered at Saudi 'highest levels'
Saudi Arabia had initially denied all accusations and insisted that Khashoggi left the consulate shortly after he arrived. Turkey is seeking the extradition of 18 suspects who were detained in Saudi Arabia so they can be put on trial in Turkey.
How Will The US Midterm Elections Impact Bitcoin
Roosevelt took a beating, losing 71 seats, according to political publication PolitiFact. So a lot needs to go right for the Democrats if they're to take control of the Senate.
The Democrats achieved the minimum they needed and retook the House to provide some sort of check on Trump while Republicans gained seats in the Senate.
Pelosi told a Washington audience that the Democrats' victories in House races on Election Day signified "restoring the Constitution's checks and balances" on the Trump administration.
"Ever since President Trump has been in office, it has just been not the country that I am used to or that I thought I would be in", said Sarah Roth, 22, a Democratic voter from Minnetonka, Minnesota.
"I am extremely happy with the economy", Gerlock said. 25 percent described health care and immigration as the most important issues in the election, according to AP VoteCast, a national survey of the electorate. Democrat Chintan Desai is trailing in the Arkansas District One seat against Republican Rick Crawford.
Republicans held the Senate.
As Election Day unfolded, Democrats were increasingly confident, predicting a House majority on the strength of voter enthusiasm, robust fundraising and unusually fresh candidates. Democratic Senate incumbents were up for re-election, for example, in North Dakota, Indiana, and Missouri - states Trump carried by nearly 25 percentage points on average two years ago.
The election near the halfway mark of a president's first term is traditionally a referendum on the White House occupant.
We'll find out if Mr Trump's final push to get his loyal supporters to the polls worked, or if this was a new wave of voters driven by a dislike of what's going on in the White House.
Record diversity on the ballot may have helped drive turnout.
In Kansas, Democrat Sharice Davids beat a GOP incumbent to become the first gay Native American woman elected to the House.
Also a record number of women - 200 Democrats and 60 Republicans - are candidates for Congress, where they now hold only about 20 percent of the seats.