The wild animal was first discovered by two people who entered the almost vacant house looking for a place to smoke marijuana, KHOU-TV reported officials as saying.
An anonymous tipster reported seeing the animal about a week ago, according to BARC.
However, a wildlife sanctuary in Texas volunteered to give the tiger a permanent home and the animal was transferred on Tuesday.
First responders reportedly nicknamed the tiger "Tyson" after the movie "The Hangover".
Police weren't sure what to make of it when they had a call from someone who admitted to smoking cannabis, but said they saw a tiger.
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The animal officers, who are more accustomed to handling dogs and cats of the smaller variety, tranquilized the tiger, loaded its cage into a horse trailer and drove it across town to the city shelter Monday, Cottingham said. "We are working to determine who owns the tiger and who owns the property because that may or may not be the same person".
Luckily, BARC was able to find a home for the tiger with a "facility that is licensed to handle exotic pets". "They saw a tiger in this building, this vacant house that's obviously been abandoned for some time". "Malayan tigers surviving on the Malay Peninsula are critically endangered with an estimated population of 300 remaining in the wild", the statement added.
Houston Police Department's Major Offenders, Livestock Animal Cruelty Unit responded to the scene, the report said.
"They can be extremely unsafe".
That awkward moment where you see a tiger and you don't know if its real or if this is some really good weed.
'There's an incredible network all across the United States and here in Houston and here in Texas. "The rest are found in other private hands".