Messi has returned to the Argentina national team set up for the first time since he participated at the 2018 FIFA World Cup in Russian Federation.
The Barcelona attacker cut a frustrated figure at full-time as his return to the worldwide fold - having taken a sabbatical following Argentina's World Cup exit last summer - ended in such disappointing fashion.
This is the first time that Messi has been in the Argentina squad since the disappointment of last summer's World Cup when La Albiceleste could only scrape through the group stage before conceding four goals against France in the first knockout round.
But he will feature from the start in Friday's friendly in Madrid as Argentina step up their preparations for the Copa América, which gets under way in less than three months.
Southgate: Hudson-Odoi ready to start for England
I think everyone looks forward to coming away with England and meeting up again. He should just do what's best for him and makes him feel good.
Millions Love Me And Not John McCain
"They got to a vote, and he said thumbs down", Trump said . "I think that's disgraceful, plus there are other things", he said. The president also tweeted that the 2008 Republican presidential candidate was "last in his class" at the U.S.
Trump Aims New Blasts at McCain, Claims Credit for Funeral
The flip side is that Trump is likely talking about McCain's family not thanking him, but this is Trump we're talking about. Trump's feud with McCain dates back to well before he was elected president.
Genetic scientists believe they could clone Lionel Messi in the future by using current scientific practices.
All-time top scorer Ronaldo, 34, was similarly returning to global action for the first time since the World Cup, but despite Portugal having 18 efforts on goal, they failed to break and obdurate Ukrainian defense.
The real Messi joined Barcelona as a tiny 13-year-old from Argentina's Newell's Old Boys.
Elsewhere on Friday, Messi's rival for generational greatness, Cristiano Ronaldo, also endured a frustrating return to worldwide football as his Portugal team were held to a 0-0 draw by Ukraine in their Euro 2020 qualifier in Lisbon.
Argentina's Martinez gave his side some hope on the hour mark as Messi found Giovanni Lo Celso who played in the Inter forward to finish.